ANTIBIÓTICOS DE ÚLTIMA GENERACIÓN: NUEVAS ARMAS FRENTE A LA RESISTENCIA BACTERIANA
Synopsis
Antimicrobial resistance constitutes one of the major threats to global public health, driven by the indiscriminate use of antibiotics and the evolutionary adaptability of microorganisms. This chapter presents a systematic review of next-generation antibiotics as key tools against multidrug-resistant bacteria. Thirty-six recent articles (2020–2025) were analyzed, evaluating new β-lactam/β-lactamase inhibitor combinations, siderophore cephalosporins, and innovative drugs such as lefamulin, delafloxacin, tedizolid, and long-acting lipoglycopeptides. The results demonstrate significant improvements in clinical efficacy, pharmacokinetics, and safety, as well as reduced mortality in nosocomial and complicated infections. Furthermore, advances in the treatment of drug-resistant tuberculosis with bedaquiline, delamanid, and pretomanid are discussed, along with the importance of antimicrobial stewardship programs (ASPs) in containing emerging resistance. Finally, the need to integrate therapeutic innovation, rapid diagnostics, and microbiological surveillance is highlighted as an essential foundation for ensuring antibiotic effectiveness in the coming decade.
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1-14
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April 21, 2026
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Copyright (c) 2026 Karla Domenica Morales Saquicela, Kevin Salvador Arévalo Goyes, Jorge Roberto Rodas Andrade, Eduardo Andrés Rojas Portéz, Marcos Andrés Calva Torres, Catalina María Hurtado, Samantha Nayeli Minchala García, Noemi Noelia Palacios Caicedo, Camila Valentina Cuesta Buestan, Juan Sebastián Urgilés Beltrán, Ibelice Salome Dután Perez, Diego Martin Reyes Novillo, María Alejandra Mantilla Vicuña, Diana Yamileth González Ortiz, Pablo Segundo Salinas Vázquez, Kevin Ismael Rojas Rojas, Dayana Mishelle Orozco Azuero, Jessica Ximena Humala Rojas, Viviana Elizabeth González Merchán, Niurka Salomé Rojas Avendaño, Andrea Rosana Mogrovejo Avila, Ainhoa Alejandra Guaraca Ortega, Wendy Valentina Mendoza Cajamarca, Dayana Estefania Sacta Rivera, Mercy Daniela Cabrera Vivar, Anabella Inés Zambrano Párrraga, Enma Jacqueline Zambrano Párraga, Anderson Israel Tenezaca Reinoso, Gladys Janneth Peñafiel Ponce, Jordan Smith Colcha González, Luis Alberto Saquicela Espinoza, Gabriela Abigail Campoverde Sigüenza, Evelyn Nathaly Morocho Bustamante, Jacinto Eugenio Pérez Ramírez, Pamela Lissette Pinargote Santana, Jonnathan Paúl Pesántez León, Wilson Javier Mendoza Saeteros, Bryan Antonio Ramón Cáceres, Ivette Denisse Quinteros Sánchez, Susan Karina Ortega Castillo, Juan Francisco Urgiles Rojas, Edith Anahel Morejón Flores, Gustavo Adolfo Espinoza Palomeque, Ana Paulina Inga Macancela, Britney Shamira Macias Zambrano, Nelly Marielena Larrea Semiterra, Omar Segundo Arévalo Goyes, Milagros Valeria González Parra, Juan Manuel González Cárdenas, Esteban Leonardo Coronel Coello, Kerly Monserrath Pinos Larrea, Juan Sebastián Crespo Domínguez, Camila Raquel González González, Larisa Araceli Hurtado Flores, María José Quevedo, Angie Patricia Mogrovejo Coronel, Luis Holguer Idrovo Becerra, Jennifer Mariuxi Álvarez Avendaño; Juan Carlos Santillán Lima
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How to Cite
ANTIBIÓTICOS DE ÚLTIMA GENERACIÓN: NUEVAS ARMAS FRENTE A LA RESISTENCIA BACTERIANA. (2026). In INFECTOLOGÍA CLÍNICA TOMO 3 (pp. 1-14). Puerto Madero Editorial Académica. https://doi.org/10.55204/pmea.128.c187
