Inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumor is an uncommon mesenchymal neoplasm of intermediate biologic potential that can arise in a wide variety of sites, most commonly in the lungs. On histology, it demonstrates polymorphous infiltration of inflammatory cells, myofibroblastic spindle cells with variable amounts of fibrosis, necrosis, and granulomatous reaction. Definitive diagnosis requires histopathological examination, immunohistochemistry and, when possible, genetic analysis by massive DNA sequencing. Total surgical resection is the therapeutic modality of choice and is associated with a high degree of prognostic significance. It tends to local recurrence and a low risk of distant metastases.